Until now, the early phase of drug discovery for the development of new therapeutics has been both cost- and time-intensive. Researchers at KIT (Karlsruhe Institute of Technology) have now developed a platform on which extremely miniaturized nanodroplets with a volume of only 200 nanoliters per droplet—comparable to a grain of sand—and containing only 300 cells per test can be arranged.
New delivery method lets cancer patients skip IVs, self-inject protein drugs at home.
Patients with cancer, autoimmune diseases, and metabolic disorders often endure hours-long intravenous infusions.
These treatments involve protein-based drugs, which must be given in high doses but remain stable only at low concentrations. Until now, IV infusions were the only option.
A Stanford research team has developed a delivery platform that changes this. The method allows protein drugs to be concentrated at far higher levels without losing stability.
Scientists in the US discovered that zinc-ion batteries could potentially replace lithium-ion ones as fast charging makes them stronger instead of wearing them down.
Led by Hailong Chen, PhD, an associate professor in the George W. Woodruff School of Mechanical Engineering at Georgia Tech, the research overturned the long-standing assumption that fast charging is risky.
Instead, the findings revealed that charging zinc-ion batteries at higher currents can extend their lifespan and potentially revolutionize how energy is delivered to homes, hospitals, and the grid.
One of the most fundamental processes in all of biology is the spontaneous organization of cells into clusters that divide and eventually turn into shapes—be they organs, wings or limbs.
Scientists have long explored this enormously complex process to make artificial organs or understand cancer growth—but precisely engineering single cells to achieve a desired collective outcome is often a trial-and-error process.
Harvard applied physicists consider the control of cellular organization and morphogenesis to be an optimization problem that can be solved with powerful new machine learning tools. In new research published in Nature Computational Science, researchers in the John A. Paulson School of Engineering and Applied Sciences (SEAS) have created a computational framework that can extract the rules that cells need to follow as they grow, in order for a collective function to emerge from the whole.
It is a very common belief that once plaque builds up in the arteries, it is there to stay, a slow, irreversible path towards heart disease. Doctors generally prescribed lifelong medication, stents, or even surgery as the only way forward. But as longevity expert Dr Vass, trained at Cornell, points out, that it might not all be true. Science now shows that arterial plaque can indeed be managed, reduced, and even stabilised if the root causes are targeted. So, can plaque really be reversed, and can this lower the risk of heart attacks? Here’s all we need to know about it.
Australian researchers have used an innovative genome-wide screening approach to identify genes, and their encoded proteins, that play critical roles in the prevention of lymphoma development, revealing new potential treatment targets for these blood cancers.
The study, published in Nature Communications, has identified a group of proteins known as the GATOR1 complex as essential tumor suppressors.
The GATOR1 complex normally functions as a “brake” on cellular growth by regulating pathways that control cell growth and metabolism. When GATOR1 components are lost or defective, this protective mechanism fails, allowing cells to grow uncontrollably.
The brain holds a “map” of the body that remains unchanged even after a limb has been amputated, contrary to the prevailing view that it rearranges itself to compensate for the loss, according to new research from scientists in the UK and US.
The findings, published in Nature Neuroscience, have implications for the treatment of “phantom limb” pain, but also suggest that controlling robotic replacement limbs via neural interfaces may be more straightforward than previously thought.
Studies have previously shown that within an area of the brain known as the somatosensory cortex there exists a map of the body, with different regions corresponding to different body parts.
Researchers can use a metric called the particle number concentration (PNC) to calculate the number of particles in a sample, such as the number of marbles in a jar.
Researchers at the National Institute of Standards and Technology (NIST) have developed a new mathematical formula to calculate the concentration of particles suspended in a solution. The new approach, which yields more accurate results than current methods, can be used to deliver the correct drug dosage to patients, measure the amount of nanoplastics in ocean water, and help ensure the correct level of additives in food products, among other applications.
The researchers have published their findings in Analytical Chemistry.