Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 74

The study of the gut microbiome, which is the total of all the microbes living in the intestines, has been shown to not only play an important role in the health of the bowel itself, but also in the health of distant organs such as the lungs. Lung cancer is one of the diseases that is often difficult to treat successfully. Rohan Kubba from the California Northstate University, Elk Grove, USA, believes that by studying the gut microbiome he can understand more about how anti-cancer treatments affect the gut–lung axis, and how the variations found in patient microbe populations are associated with treatment outcomes.

The microbiome consists of thousands of species including bacteria, fungi, and viruses (microbiota). Each person has an entirely unique network of microbiota, most of them living in their gut but also on the skin, mouth, and lungs. Each person’s microbiome is formed by a combination of factors, including but not limited to exposure to microorganisms during natural birth, consuming their mother’s milk, and later on in life, environmental factors such as diet.

Gut microbiome and disease.

Read more | >

Competitive interactions modify the direct effects of climate.

As the climate is changing, species respond by changing their distributions and abundances. The effects of climate are not only direct, but also occur via changes in biotic interactions, such as competition. Yet, the role of competition in mediating the effects of climate is still largely unclear. To examine how climate influences species performance, directly and via competition with other species, we transplanted two moss species differing in climate niches, alone and together at 59 sites along a climate gradient. Growth was monitored over three growing seasons. In the absence of competition, both species performed better under warmer conditions. Yet, when transplanted together, a warmer climate had negative effects on the northern moss, while the effects remained positive for the southern species. The negative effect of a cold climate on the southern species was larger when both species were transplanted together. Over three growing seasons, the southern species almost outcompeted the northern in warmer climates. Our results illustrate how competitive interactions can modify, and even reverse, the direct effects of climate on organism performance. A broader implication of our results is that species interactions can have important effects on how environmental and climate change influence performance and abundance.

Read more | >

Though he doesn’t remember it, Branden Baptiste had his first sickle cell crisis at age 2. Through elementary school, he was in and out of the hospital with pain episodes, not knowing why. As he got older, he learned he had sickle cell disease. His red blood cells were forming sickle shapes and getting stuck in his blood stream, preventing oxygen from reaching his tissues.

“Sickle cell disease has a broad spectrum of severity, and the severity and frequency of complications can wax and wane,” says Matthew Heeney, MD, Branden’s long-time hematologist at Boston Children’s Hospital.

“Unfortunately, Branden was quickly acquiring many of the chronic complications of sickle cell disease, including organ dysfunction affecting his kidneys, lungs, joints, and eyes.”

Read more | >

What’s the best way to precisely manipulate a material’s properties to the desired state? It may be straining the material’s atomic arrangement, according to a team led by researchers at Penn State. The team discovered that “atomic spray painting” of potassium niobate, a material used in advanced electronics, could tune the resulting thin films with exquisite control.

The finding, published in Advanced Materials (“Colossal Strain Tuning of Ferroelectric Transitions in KNbO 3 Thin Films”), could drive environmentally friendly advancements in consumer electronics, medical devices and quantum computing, the researchers said.

The process, called strain tuning, alters a material’s properties by stretching or compressing its atomic unit cell, which is the repeating motif of atoms that builds up its crystal structure. The researchers use molecular beam epitaxy (MBE), a technique that involves depositing a layer of atoms on a substrate to form a thin film. In this case, they produced a thin film of strain-tuned potassium niobate.

Read more | >

Investigating how proteins interact is key to understanding how cells work and communicate. In a new study published in Nature Communications, FMI researchers have provided key insights into how protein interactions are governed and how mutations influence cellular functions.

Proteins are the molecular machines of life, performing tasks ranging from driving to orchestrating cell communication. For these tasks, proteins must bind to the right partners with precision, avoiding mispairings that could disrupt cellular processes and lead to disease.

Scientists have long been curious about how changes in the —the building blocks of proteins—can alter a protein’s binding capabilities. To investigate this question, researchers in the Diss lab analyzed the effects of all possible mutations in a single protein across its with an entire family of partner proteins. They focused on a protein called JUN, which plays a key role in DNA binding and cellular communication.

Read more | >

Using an innovative approach, EMBL scientists uncovered key interactions between molecular machines, potentially opening new avenues for drug development.

Choosing a film for a movie night is always a battle. Now imagine if you could pick one that provided a window into some of the most fundamental biological processes that keep us alive. For the first time ever, researchers have captured a real-time molecular movie to show how two essential cellular processes – transcription and translation – interact with each other in bacteria.

In all living organisms, DNA contains the code that defines cellular structures and functions. An enzyme called RNA polymerase deciphers this code and converts it into RNA, a molecule that closely resembles DNA. This transfer of life’s code from DNA to RNA is called transcription. Next, a molecular machine called ‘ribosome’ uses the message encoded in RNA to build proteins – the molecules performing most of the essential functions of our cells. This process is called translation.

Read more | >

Scientists from the Longevity Research Institute (LRI), which was formed by the merger of SENS Research Foundation and Lifespan.io, have achieved expression of an essential mitochondrial gene in the nucleus and proper functioning of the protein. This could pave the way for curing diseases caused by mitochondrial mutations [1].

The fragile mitochondrial DNA

The prevailing scientific consensus is that mitochondria were once independent microorganisms that entered a symbiotic relationship with larger cells. This duo gave rise to eukaryotic cells: the building blocks of all multicellular life. Without that fateful “marriage,” complex life would not exist, as mitochondria provide cells with essential energy via oxidative phosphorylation.

Read more | >

The Netherlands Cancer Institute has found that the estrous cycle stage significantly influences mammary tumors’ sensitivity to chemotherapy. In mouse models of breast cancer, treatment initiated during the diestrus stage resulted in reduced responses to chemotherapy compared to initiation during the estrus stage.

The human body contains internal timekeeping clocks to adapt to environmental changes, including infradian rhythms like the . Fluctuating during these cycles regulate physiological adaptations, which may impact responses to therapies.

Understanding factors that contribute to the heterogeneity in responses is crucial for improving treatment outcomes in .

Read more | >

Siddarth Kara’s bestseller, “Cobalt Red: How the Blood of Congo Powers Our Lives,” focuses on problems surrounding the sourcing of cobalt, a critical component of lithium-ion batteries that power many technologies central to modern life, from mobile phones and pacemakers to electric vehicles.

“Perhaps many of us have read how are vital for energy storage technologies,” says Eric Schelter, the Hirschmann-Makineni Professor of Chemistry at the University of Pennsylvania. “But how materials that make up such batteries are sourced can be concerning and problematic, both ethically and environmentally.”

Schelter says that mining in the Democratic Republic of Congo, which supplies about 70% of the world’s cobalt, raises concerns due to environmental degradation and unsafe working conditions, and that large-scale mining disrupts ecosystems and can contaminate , leaving lasting environmental damage. In addition, he notes that a looming cobalt shortage threatens to strain as demand for battery technologies continues to grow.

Read more | >