In this Research Article, Sanjana Dayal report on a link between prediabetes, platelet activation, and thrombosis:
The images show platelet accumulation after 5 minutes of continuous flow on a collagen-coated chamber.
Address correspondence to: Sanjana Dayal, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 100D EMRB, 500 Newton Road, Iowa City, Iowa, 52,242, USA. Phone: 319.335.7712; Email: [email protected].
(IFNs) are a family of antiviral and immunomodulatory signaling proteins produced by host cells to fight pathogens like viruses, bacteria, and tumors.
As cytokines, they alert neighboring cells to activate defenses, inhibit viral replication, and regulate immune responses.
Common uses include treating hepatitis B and C, multiple sclerosis, and certain cancers like melanoma and lymphoma.
For more information click on the link below: sciencenewshighlights ScienceMission.
A study published in the Chemical Engineering Journal proposes a new approach to environmental remediation of pharmaceutical pollutants in water flows. This approach is based on a phenomenon known as “sparks,” which refers to the sparks that appear on the surface of a metal when it is subjected to plasma electrolytic oxidation (PEO).
During PEO, a metal part (in this case, aluminum) is immersed in a liquid to which an electrical voltage is applied. This results in the growth of an oxide coating. During the process, micro-electrical discharges, or sparks, appear. These sparks last for fractions of a second and cover a small area. However, they lead to very high temperatures, which is why they are nicknamed the “second sun.” This treatment is used on aluminum, magnesium, titanium, and other metal parts in the aerospace, automotive, medical, and electronics industries to create an oxide coating that improves the resistance of the material to corrosion and heat.
Minor changes in moisture level can promote lipid molecules to reorganize themselves in biomaterial or biomembranes. This can affect how the skin, lungs and tear film protect us from dehydration. This new discovery from Lund University in Sweden could be the inspiration for smart materials and new drug delivery techniques.
Imagine a membrane that separates dry air from a moist interior. When moisture levels become lower, the lipid molecules organize themselves in an adaptive way—and now researchers in Lund have characterized this process.
“What surprised me was how powerful the sorting of the lipid molecules was even at small changes in the moisture level. I had not expected this based on what we know about the systems in conditions where there is no evaporation,” says Nikol Labecka, researcher in chemistry at Lund University.
Bill Faloon presents about thymosin’s potential in 4-minute video excerpt from recent super-longevity presentation. Click the video below to view the presentation.
Lactation supports babies’ immune health and reduces the risk of breast cancer for the mother.
TrendsInImmunology.
Lactation is increasingly recognized as an immune-regulated process. Immune cells shape mammary gland development, coordinate tissue remodeling, and aid in milk production with lasting consequences for maternal health. Here, we summarize recent advances on the roles and dynamics of T cells in the mammary gland during lactation and beyond.
Degs1-related hypomyelinating leukodystrophy: four individuals from same family and review of literature.
ObjectivesDEGS1-related leukodystrophy has been described in 33 individuals to date with varying degrees of neurologic symptoms and atrophy/hypomyelination on MRI brain. We describe a family of 4 individuals with DEGS1-related leukodystrophy with phenotypic heterogeneity both within the family and in previously reported individuals.
New research reveals that LINE-1 retrotransposons don’t just nudge genes, they also trigger massive structural upheavals early in cancer development.
Read about the findings.
Where there’s a bountiful host, there are parasites ready to take advantage of the resources. This holds true even at microscopic levels. Lying within human DNA are repetitive elements called LINE-1 (L1) retrotransposons that promote their own propagation at the cost of the host organism’s health.1 These genetic parasites create copies of themselves that then get inserted at new locations within the genome. Until recently, scientists thought that the activity of L1s mostly resulted in local alterations to genes.
Now, in a new study published in Science, researchers have demonstrated that L1s can trigger dramatic structural changes in DNA, resulting in cancer-causing mutations.2 These findings, which shed light on the intricate relationship between cancer evolution and the genome, could lead to improved diagnostic and therapeutic strategies for different cancers.
“Cancer genomes are more influenced by these jumping fragments of DNA parasites than we previously thought,” said José Tubio, a molecular biologist at the University of Santiago de Compostela, in a statement.