Lifeboat Foundation

The following press release was written and and published by the Defense Advanced Research Projects Agency (DARPA) and originally published on their website. Click here to see the original version of this post.

On a recent sunny fall day in the nation’s capital, several hundred volunteers—each toting a backpack containing smartphone-sized radiation detectors—walked for hours around the National Mall searching for clues in a “whodunit” scavenger hunt to locate a geneticist who’d been mysteriously abducted. The geneticist and his abduction were fictitious. But the challenge this scavenger hunt was designed to address is real: The need to detect even small quantities of radioactive material that terrorists might try to bring into an urban area with the intent of detonating a “dirty bomb,” or worse. By getting volunteers to walk all day looking for clues, the DARPA-sponsored exercise provided the largest test yet of DARPA’s SIGMA program, which is developing networked sensors that can provide dynamic, real-time radiation detection over large urban areas.

Continue reading “Advanced Radioactive Threat Detection System Completes First Large-Scale Citywide Test” »

Why Synbio computing is where we ultimately want to more and more progress towards especially once the basic infrastructure is updated with technology like QC.

Cells are often likened to computers, running an operating system that receives signals, processes their input, and responds, according to programming, with cellular output. Yet untangling computer-like pathways in cells is anything but simple, say Denise Montell, professor at the University of California, Santa Barbara, and Aviv Regev, a Howard Hughes Medical Institute investigator at the Massachusetts Institute of Technology and the Broad Institute. However, both are eager to try and will outline their latest efforts at the “Logic of Signaling” symposium at the 2016 ASCB Annual Meeting.

“My lab is understanding how cells maintain and build normal tissues. We’re studying cellular behaviors that underlie normal behavior and tumor metastasis, a great unsolved question in cancer,” Montell said. Her lab recently discovered that cells can bounce back from the brink of apoptotic cell death. “This wasn’t known before so now we’re looking at how cells do it, when do they do it, under what circumstances, and what does it mean,” Montell said.

Continue reading “Logic of Signaling” »

On Tuesday, the two feuding parties of the CRISPR gene editing patent fight entered the boxing ring: attorneys for each side made oral arguments before three-judge panel, in a case that not only puts billions of potential dollars at stake, but could define the future of genetic engineering.

In Brief

• By observing the transparent cells of roundworms, researchers have uncovered a link between lifespan and the natural cellular process of RNA splicing.
• This research could lead to new breakthroughs in anti-aging treatments that would allow humans to indefinitely keep ourselves healthy, stalling death for as long as possible.

Though aging seems like one of the most natural things, an affair common to all living creatures, the process is actually poorly understood by scientists. A new study detailed in Nature aims to shed light on the phenomenon as a research team led by the Harvard T.H. Chan School of Public Health has uncovered a relationship between lifespan and RNA splicing, a core function of cells that allows a single gene to produce a variety of proteins.

The researchers already knew that mutations in RNA splicing could lead to disease, but they wanted to find out if the act of splicing itself had an impact on the aging process. To find out, they designed experimental setups using the roundworm Caenorhabditis elegans, which show visible signs of aging during their short three-week lifespan.

Continue reading “A New Aging Discovery Could Allow Humans to Extend Their Lifespan” »

Hemophilia is a devastating genetic condition—without the ability to form blood clots, those who have it risk bleeding to death from even the slightest cut.

Great.

Research published in Acta Neuropathologica, identified alterations in a protein known as ATRX in human brain tumours; researchers might also be able to target microRNAs directly, altering their levels to make cancer cells less likely to form tumours.

A recent study suggests that two recently discovered genetic differences between brain cancer cells and normal tissue cells could offer clues to tumour behaviour and potential new targets for therapy.

Continue reading “Research sets new target for brain cancer therapy” »

DARPA scientists think they can use insects to deliver genetic changes to crops.

These desktop gadgets should make DIY genetic engineering much easier.

Harvard bioethics specialist Glenn Cohen considers the complex question of whether humans should mix their genetic material with other animals to create chimeras.