Lifeboat Foundation

https://music.youtube.com/watch?v=n_LefGJgOJ8&si=UoInnL8Xy_wsXv_

Currently listening to this. He’s pretty decent, up there with Dr Daniel Amen in advancement/ideas. I barely started this episode but it seems AI can help in medicine and there’s more in this podcast concerning our personal health. This is some key issues for longevity.

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Continue reading “Shocking Truth About AI, Chronic Disease, Toxins, Diet & Lifestyle For Longevity | Eric Topol” »

The authors of a recent review published in Ageing Research Reviews summarize the research on epigenetic reprogramming and its potential as a rejuvenation therapy [1].

Aging leads to changes in the epigenome. Those changes can lead to alterations in gene regulation, affecting cellular homeostasis, and can play a role in age-associated phenotypes. Epigenetic modifications, the addition or removal of chemical groups to the DNA or DNA-associated proteins, have a profound impact on gene expression, tissue functions, and identity [2].

This review’s authors believe epigenetic reprogramming to be among the most currently promising interventions to stop or delay aging, potentially even reversing it at the cellular level. They believe that epigenetics are the basis of aging; therefore, being able to impact the epigenome would allow them to address multiple Hallmarks of Aging simultaneously.

Human telomerase threatens genome integrity by adding telomeres to broken chromosomes and is held in check by ATR kinase signaling.

One of the ways cells in different kinds of tissue communicate is by exchanging RNA molecules. In experiments with roundworms of the species Caenorhabditis elegans, researchers at the State University of Campinas (UNICAMP) in Brazil found that when this communication pathway is dysregulated, the organism’s lifespan is shortened.

An article on the study is published in the journal Gene. The findings contribute to a better understanding of the aging process and associated diseases.

“Previous research showed that some types of RNA can be transferred from one cell to another, mediating intertissue communication, of the kind that occurs with proteins and metabolites, for example. This is considered a mechanism for signaling between organs or neighboring cells. It’s part [of the physiopathology] of several diseases and of the organism’s normal functioning,” said Marcelo Mori, corresponding author of the article and a professor at the Institute of Biology (IB-UNICAMP).

The natural ends of chromosomes appear alarmingly like broken DNA, much as a snapped spaghetti strand is difficult to distinguish from its intact counterparts. Yet every cell in our bodies must have a way of differentiating between the two because the best way to protect the healthy end of a chromosome also happens to be the worst way to repair damaged DNA.

Consider the enzyme telomerase, which is responsible for maintaining protective telomeres at the natural ends of chromosomes. Were telomerase to seal off a broken strand of DNA with a telomere, it would prevent further repair of that break and delete essential genes.

Now, a new study in Science describes how cells avoid such mishaps. These findings show that telomerase can indeed run amok, adding telomeres to damaged DNA, and would do so were it not for the ATR kinase, a key enzyme that responds to DNA damage.

More than 4,500 heart transplants were performed in the U.S. in 2023. While the lifesaving operation improves the quality of life and longevity for most recipients, organ rejection remains a risk, with acute rejection occurring in up to 32% of recipients within the first year.

A team of researchers from Emory University, Case Western Reserve University and the University of Pennsylvania developed artificial intelligence tools to examine cardiac biopsy images to improve the prediction of rejection, helping to ensure patients receive the best possible post-transplant treatment.

Currently, clinicians rely on histologic grading of cardiac biopsies to diagnose acute rejection. However, there are limitations to the method, which assigns International Society of Heart and Lung Transplantation (ISHLT) histologic grades corresponding to no, mild, moderate and severe rejection.

Like in many other species, it seems caloric restriction may be the most effective dog longevity diet:

What’s the best dog longevity diet? We read the science behind raw feeding, dried kibble, and caloric restriction and found a clear winner.

Summary: Researchers developed 20 novel recombinant rabies viral vectors that present unparalleled advantages for neural circuit mapping in aging and Alzheimer’s disease studies. These vectors are engineered to highlight microstructural changes in brain neurons through enhanced fluorescent proteins, offering insights into neural networks at both micro and macro scales.

The vectors’ unique ability to target specific neuron components and perform live imaging makes them potent tools for dissecting neural circuitry in healthy and diseased states. This innovation opens new pathways for targeted treatment strategies and will be shared with the neuroscience community through UCI’s Center for Neural Circuit Mapping.

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