Toggle light / dark theme

I think this could lead to immortality basically allowing for limited growth of dna structures but still offering unlimited lifespan. In short this also prevents cancer aswell.


Telomerase is a ribonuceloprotein complex responsible for maintaining telomeres and protecting chromosomal integrity. The human telomerase reverse transcriptase (hTERT) is expressed in ∼90% of cancer cells where it confers the capacity for limitless proliferation. Along with its established role in telomere lengthening, telomerase also serves noncanonical extra-telomeric roles in oncogenic signaling, resistance to apoptosis, and enhanced DNA damage response. We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site.

This also an amazing supplement that also exists in all foods called nad plus that stops age related symptoms.


Nicotine, a metabolite of the NAD+ metabolic pathway, has been found to possess anti-inflammatory and neuroprotective properties, yet the underlying molecular mechanisms remained unknown. Here, the authors show that low-dose nicotine promotes SIRT1 deacetylation of NAMPT and enhanced NAMPT activity which boosts NAD generation and improves age related symptoms.

Though hardly conclusive, this study strongly suggests that boosting NAD+ levels in humans could have incredible health benefits.

That’s where Basis comes in.

Created by Elysium Health, Basis is a proprietary formulation of crystalline nicotinamide riboside and pterostilbene, which the human body converts into NAD+. In a double-blind, randomized, placebo-controlled clinical trial, it was demonstrated that, on average, Basis increases NAD+ levels by 40 percent. These elevated NAD+ levels won’t necessarily stop the aging process. But they will certainly maximize cellular health, boost energy, and support healthy sleep. This in turn should allow people who are in good health to maintain it longer, and thus age better.

He added: “Their target: follistatin gene therapy. A pioneering technology with the potential to improve muscle and strength [and] slow the speed of aging and many more benefits.”

The millionaire explained that the procedure involves an injection in the stomach and in the buttocks.

It also costs $20,000, so not exactly cheap.

From the article:

Longtermism asks fundamental questions and promotes the kind of consequentialism that should guide public policy.


Based on a talk delivered at the conference on Existential Threats and Other Disasters: How Should We Address Them? May 30–31, 2024 – Budva, Montenegro – sponsored by the Center for the Study of Bioethics, The Hastings Center, and The Oxford Uehiro Center for Practical Ethics.

For twenty years, I have been talking about old age dependency ratios as an argument for universal basic income and investing in anti-aging therapies to keep elders healthy longer. A declining number of young workers supporting a growing number of retirees is straining many welfare systems. Healthy seniors are less expensive and work longer. UBI is more intergenerationally equitable, especially if we face technological unemployment.

For over five decades, futurist Raymond Kurzweil has shown a propensity for understanding how computers can change our world. Now he’s ready to anoint nanorobots as the key to allowing humans to transcend life’s ~120-year threshold.

As he wrote—both in the upcoming The Singularity is Nearer book (set for release on June 25) and in an essay published in Wired —the merging of biotechnology with artificial intelligence will lead to nanotechnology helping “overcome the limitations of our biological organs altogether.”

As our bodies accumulate errors when cells reproduce over and over, it invites damage. That damage can get repaired quickly by young bodies, but less so when age piles up.