Researchers have identified genes influencing muscle aging, including USP54, using AI analysis of gene expression data. These findings may lead to drug discovery and exercise-based interventions targeting muscle mass preservation.
Category: life extension – Page 53
The great George Church takes us through the revolutionary journey of DNA sequencing from his early groundbreaking work to the latest advancements. He discusses the evolution of sequencing methods, including molecular multiplexing, and their implications for understanding and combating aging.
We talk about the rise of biotech startups, potential future directions in genome sequencing, the role of precise gene therapies, the ongoing integration of nanotechnology and biology, the potential of biological engineering in accelerating evolution, transhumanism, the Human Genome Project, and the importance of intellectual property in biotechnology.
The episode concludes with reflections on future technologies, the importance of academia in fostering innovation, and the need for scalable developments in biotech.
00:00 Introduction to Longevity and DNA Sequencing.
01:43 George Church’s Early Work in Genomic Sequencing.
02:38 Innovations in DNA Sequencing.
03:15 The Evolution of Sequencing Methods.
07:41 Longevity and Aging Reversal.
12:12 Biotech Startups and Commercial Endeavors.
17:38 Future Directions in Genome Sequencing.
28:10 Humanity’s Role and Transhumanism.
37:23 Exploring the Connectome and Neural Networks.
38:29 The Mystery of Life: From Atoms to Living Systems.
39:35 Accelerating Evolution and Biological Engineering.
41:37 Merging Nanotechnology and Biology.
45:00 The Future of Biotech and Young Innovators.
47:16 The Human Genome Project: Successes and Shortcomings.
01:01:10 Intellectual Property in Biotechnology.
01:06:30 Future Technologies and Final Thoughts.
As Canadians brace for “vitamin D winter”—months when the sun’s angle is too low to produce the vitamin in the skin—a McGill University study explains why vitamin D deficiency early in life is associated with a higher risk of autoimmune diseases.
During childhood, the thymus helps train immune cells to distinguish between the body’s own tissues and harmful invaders. A vitamin D deficiency at that stage of life causes the thymus to age more quickly, the researchers discovered.
The study is published in the journal Science Advances.
A simple cheek swab test called CheekAge may be able to predict a person’s increase in mortality risk, according to its developers.
Yay face_with_colon_three
Researchers discovered that PLK1 triggers a process ensuring centromere preservation during cell division by activating the Mis18 complex and controlling CENP-A loading. This finding is key to understanding how cells correctly divide their genetic material, preventing diseases like cancer.
Scientists have resolved a decade-long mystery about the mechanism that maintains the centromere, the crucial region responsible for ensuring accurate DNA division during cell division.
A study revealed that a protein, known as PLK1, triggers a process that coordinates key proteins at the right place and time during cell division – ensuring each new cell has a centromere in the right location.
The gut-brain axis has long been a subject of interest in lifespan research, and GLP-1 agonists, already used in the treatment of obesity and diabetes, are showing promise in the field of healthspan therapeutics.
New research on gut-to-brain signaling uncovers potential links between gut hormones like GLP-1 and longevity.
Intestinal stem cells play an important role in maintaining intestinal homeostasis and repairing damaged epithelial tissue. These cells function in a regenerative manner to generate new tissue throughout the growth phase and repair damaged tissue during the aging process.101 The interactions between the gut microbiome and intestinal stem cells are crucial because, if this interaction is comprehended, it may be possible to address various disorders that require stem cell therapy, heal wounds, and improve the durability of organ transplants.101 A recent study showed a connection between hematopoietic stem cells and the microbiome through altering metabolic stress.66 Therefore, the microbiota is crucial for maintaining microbial homeostasis, regulating metabolism, and the innate and adaptive immune systems.101 Furthermore, the study reveals that compositional alterations in the gut microbiome driven by dysbiosis are related to stem cell aging, metabolic dysregulations, stem cells’ epigenetic instability, and abnormal immune system activation.66
In the field of anti-aging, stem cells are regarded to have great potential. In numerous organs, it has been demonstrated that as we age, stem cells lose their capacity for self-renewal and differentiation and run out of resources.89 The emergence of anti-aging medications should address the dysregulation caused by aging that affects stem cells’ capacity for differentiation and self-renewal by re-regulating intrinsic and extrinsic variables. The host microbiome, hormones, local immune system, systemic inflammation, and niche structure are just a few examples of microenvironmental and systemic factors that influence stem cell aging.66
Endogenous ethanol is a class of microbiological metabolites. Proteobacteria, including E. coli and other Enterobacteriaceae, produce ethanol with bacterial origins. High endogenous ethanol levels in the human hippocampus inhibit proliferating stem cells and reduce progenitor and stem cells.102 Additionally, when more ethanol accumulates in the gut, it enhances the permeability of the gut by disrupting epithelial tight junctions, particularly zonula occludens. This enables the movement of pathogenic microbes, their endotoxins, and ethanol across the epithelial layer, causing more immediate and adverse effects on tissues. As a result, the stem cell reserve depletes, hastening the aging process and compensating for damaged tissues.103
Source: Nottingham Trent University.
Scientists have identified previously unreported genes which appear to play a key role in the muscle aging process. It is hoped that the findings from a Nottingham Trent University study could be used to help delay the impact of the aging process.
The study, which also involved Sweden’s Karolinska Institute, Karolinska University Hospital, and Anglia Ruskin University, is reported in the Journal of Cachexia, Sarcopenia and Muscle.
A new University of Maryland-led discovery could spur the development of new and improved treatments for Hutchinson-Gilford progeria syndrome (HGPS), often simply called “progeria”—a rare genetic disorder with no known cure that causes accelerated aging in children.
Publishing in the journal Aging…
Researchers identify protein that could improve cardiovascular health of those with progeria.
A team at Kumamoto University has made a discovery that could help promote healthy aging. As the world’s population ages, Japan’s aging population in particular is growing at an unprecedented rate, making it crucial to extend healthy lifespans rather than just lifespans.