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Category: life extension – Page 568

Top Researchers Want to Beat Back Our Chronic Diseases of Aging

Summary: A sneak peek of an upcoming documentary takes us inside the minds of the leaders in the life extension field and their recent discoveries to ward off the diseases of aging. [This article has been updated and first appeared on LongevityFacts. Author: Brady Hartman.]

Leaders in the field of longevity research plan to help us live healthier, longer lives with their recent scientific discoveries.

Sixteen of the leading scientists in the field of life extension, called geroscientists, are showcased in a new PBS documentary called “Incredible Aging: Adding Life to Your Years.”

Researchers Paint Bullseye on Target to Stop Tumor Metastasis

Summary: In a medical first, UT Dallas researchers just found a way to paint a bullseye target on cancer stem cells, the source of tumor metastases which spread through the body to cause 90% of all cancer deaths. [This article first appeared on LongevityFacts. Author: Brady Hartman. ]

Researchers with the University of Texas at Dallas just found a way to isolate and tag cancer stem cells, the chief culprit involved in cancer spreading to other parts of the body – the cause of 90% of all cancer deaths.

While they haven’t developed drugs that eliminate these aggressive cancer cells, they can paint a bright bullseye on their elusive target, making it easier to kill cancer stem cells.

Team develops 3D tissue model of a developing human heart

Utilizing induced pluripotent stem cells for regenerative medicine.

The #heart is the first organ to develop in the womb and the first cause of concern for many parents.

For expecting mothers, the excitement of pregnancy is often offset by anxiety over medication they require. Parents and doctors often have to consider the mother’s health as well as the potential risk regarding how medication could affect their baby. The U.S. Food and Drug Administration requires certain drugs to be labeled with pregnancy exposure and risk. Some drugs are labeled to show that testing on animals has failed to demonstrate a risk but there are no adequate and well-controlled studies of pregnant women.

“Some drugs are difficult for doctors to prescribe to pregnant women because they don’t know the embryo toxicity, how does that effect fetal development,” said biomedical engineering Professor Zhen Ma. “They don’t have the clinical outcome based on human study.”

Undoing Aging With Aubrey de Grey Part Three

Parte 3 of the SENS Research Foundation interview by LEAF is out!

Welcome to part three and the final part of our SENS Undoing Aging 2018 interview; we have a few more scientific questions today for Aubrey and his team as well as questions about future developments and taking new therapies to market.

Dr. de Grey, has your position on the relevance of telomere attrition changed since you first devised SENS, especially in the light of the recent results with fibrosis and your involvement with AgeX?

Aubrey: No. Let’s start with the big picture. Neither I nor anyone sensible has ever suggested that telomere attrition has no functional effects in aging: telomere attrition causes cells to become senescent and runs down the proliferative capacity of stem cells, amongst other things. Nor have I suggested that there wouldn’t be some short-term health benefits to activating telomerase or telomerase gene therapy in aging animals or animal models of age-related disease (or even their human equivalents). Indeed, there was plenty of animal data to support this long before the recent results with a mouse model of idiopathic pulmonary fibrosis (IPF)[1].

Undoing Aging With Aubrey de Grey Part Two

The second part of LEAF’s interview with the SENS Research Foundation team is out!

Welcome to part two of our three-part Undoing Aging 2018 interview of Dr. Aubrey de Grey and his team at SENS Research Foundation. Today, we have some of the scientific questions that the community had about SENS; there are some very detailed responses, and we hope you enjoy them.

Regarding the use of senolytics, are you concerned about their potential to remove highly specialized cells like cardiomyocytes, which do not divide or do so very slowly? Could taking senolytics without the ability to replace these specialized lost cells be risky unless combined with replacement therapies?

Aubrey: This is not a major concern, for a few reasons. First, when cells turn senescent, they cease carrying out their specialized function (as a cardiomyocyte, or neuron, or what have you), so no such function is lost by ablating them. Second, cells that don’t divide (like cardiomyocytes and neurons) are far less likely to become senescent in the first place than cell types that divide; many of the main drivers of senescence are related to cell division. And third, in the specific case of cardiomyocytes, there’s already significant evidence in rodents that it improves cardiac function overall [1] as well as wider cardiovascular health [2–3].

Silicon Valley billionaire pays $10k to be killed and have his brain preserved

A SILICON Valley billionaire is paying the ultimate price for the chance of immortality: death.

Well that, and a spare ten grand.

Entrepreneur Sam Altman is one of 25 people who have splashed the cash to join a waiting list at Nectome – a startup that promises to upload your brain into a computer to grant eternal life to your consciousness.

Mad Scientists Want to 3D Print Every Dead Person Back to Life

This major religious site suggests I’m part of a group of mad scientists, but Quantum Archaeology is a very interesting idea that more people should ponder. The article also highlights the challenge of #transhumanism vs. religion and conservative attitutes: http://www.lifenews.com/2018/03/12/mad-scientists-want-to-3-…k-to-life/ #transhumanism

But the self-described secular transhumanist is perfectly serious in his posturing about the future of technology, life and death. Within 50 years, he believes scientists may be able to bring back people from the dead.

“After all, everything is matter and energy. And human life, human thoughts and human existence are mathematical, determinable calculations of that subatomic world of matter and energy,” Istvan writes.

“As a secular transhumanist—someone who advocates for improving humanity by merging people with machines—I don’t believe in death anymore,” he continues. “Most transhumanists’ number one goal is to become immortal through science.”

Though he does not lump himself into this camp, he says some transhumanists want to bring back every life who ever lived.

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