Lifeboat Foundation

Aging is the major risk factor for the development of chronic diseases such as cardiovascular disease, cancer, diabetes, and dementia. Therefore, drugs that slow the aging process may help extend both lifespan and healthspan (the length of time that people are healthy).

In a study published online on February 29 in Medical Research Archives, Albert Einstein College of Medicine researchers evaluated U.S. Food and Drug Administration-approved drugs for their anti-aging potential. In ranking those drugs, they gave equal weight to preclinical studies (i.e., effect on rodent lifespan and healthspan) and clinical studies (i.e., reduced mortality from diseases the drugs were not intended to treat). The four therapeutics judged most promising for targeting aging were SGLT2 inhibitors, metformin, bisphosphonates, and GLP-1 receptor agonists. Since these drugs have been approved for safety and used extensively, the researchers recommend they be evaluated for their anti-aging potential in large-scale clinical trials.

The study’s corresponding author was Nir Barzilai, M.D., director of Einstein’s Institute for Aging Research, professor of medicine and of genetics and the Ingeborg and Ira Leon Rennert Chair in Aging Research at Einstein, and a member of the National Cancer Institute–designated Montefiore Einstein Comprehensive Cancer Center. The lead author was Michael Leone, a medical student at Einstein.

which is widely believed to be the root cause of many age-related diseases.

The study, published today in the journal npj Aging, raises the exciting possibility of a protective agent that could dampen age-related inflammation and restore normal immune function in older adults.

PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) was initially identified at the University of Birmingham in 2015. While the role of the PEPITEM pathway has already been demonstrated in immune-mediated diseases, this is the first data showing that PEPITEM has the potential to increase healthspan in an aging population.

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A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division. The findings, published in Cell, could one day lead to new interventions for a variety of conditions associated with aging, including neurodegenerative and cardiovascular diseases, diabetes, and cancer, as well as new therapies for a collection of diseases known as ribosomopathies.

“There is great interest in reducing senescence to slow or reverse aging or aging-associated diseases. We discovered a noncoding RNA that when inhibited strongly impairs senescence, suggesting that it could be a therapeutic target for conditions associated with aging,” said Joshua Mendell, M.D., Ph.D., Professor of Molecular Biology and a member of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern. He is also a Howard Hughes Medical Institute Investigator.

Dr. Mendell led the study with co-first authors Yujing Cheng, Ph.D., a recent graduate of the Genetics, Development, and Disease graduate program; and Siwen Wang, M.D., a former postdoctoral researcher, both in the Mendell Lab.

Unfortunately, while the science behind sauna use for longevity seems more convincing than cold plunging, saunas themselves cost a lot more than cold plunges…

Heat therapy seems to be good for longevity, so we looked around for the top-rated home saunas to bring those health benefits to you.

Is it possible to live to 120? Yes, according to the burgeoning field of longevity science. Over twelve weeks, reporter Darren Mara puts his own body to the test to find out if aging really is a thing of the past.

Catch The Feed Tuesdays at 10pm on SBS HD, or on SBS On Demand.

Continue reading “The End of Aging episode 1: Is it possible to live to 120?” »

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Pain management is an important component of caring for adults with cerebral palsy. However, it’s the least understood comorbidity in the adult cerebral palsy population.

A study led by Mark Peterson, Ph.D., M.S., FACSM, a professor of physical medicine and rehabilitation at University of Michigan Health, found that adults living with cerebral palsy had a very high occurrence of pain, with 90% having a pain history and 74% having multiple diagnoses of pain coming from different origins such as the lower back, irritable bowels, joint arthritis and chronic headaches.

The research is published in the journal JAMA Neurology.

(THE CONVERSATION) Racism steals time from people’s lives – possibly because of the space it occupies in the mind.

Question Is racial discrimination associated with brain connectivity, and are alterations in deep brain functional connectivity associated with accelerated epigenetic aging?

Findings In this cohort study of 90 Black women in the US, higher self-reported racial discrimination was associated with greater resting-state functional connectivity (RSFC) between the locus coeruleus (LC) and precuneus. Significant indirect effects were observed for the association between racial discrimination frequency and DNA methylation age acceleration.

Continue reading “Racial Discrimination, Neural Connectivity, and Epigenetic Aging in Black Women” »