Antibody-mediated depletion of myeloid-biased haematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system.
Category: life extension – Page 81
Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium to maintain organismal homeostasis. Aging, however, significantly reduces intestinal regenerative capacity. While cellular senescence is a key feature of the aging process, little is known about the in vivo effects of senescent cells on intestinal fitness. Here, we identify the accumulation of senescent cells in the aging gut and, by harnessing senolytic CAR T cells to eliminate them, we uncover their detrimental impact on epithelial integrity and overall intestinal homeostasis in natural aging, injury and colitis. Ablation of intestinal senescent cells with senolytic CAR T cells in vivo or in vitro is sufficient to promote the regenerative potential of aged ISCs. This intervention improves epithelial integrity and mucosal immune function. Overall, these results highlight the ability of senolytic CAR T cells to rejuvenate the intestinal niche and demonstrate the potential of targeted cell therapies to promote tissue regeneration in aging organisms.
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In a recent study published in the journal Nature Aging, researchers assessed the added predictive value of integrating polygenic risk scores (PRSs) and gut microbiome scores with conventional risk factors for common diseases in a long-term cohort study.
Analysis: Integration of polygenic and gut metagenomic risk prediction for common diseases. Image Credit: remotevfx.com / Shutterstock.
Background
Multiomic technologies are transforming disease prediction by integrating genomic and microbiomic data, offering new insights into age-related conditions like heart disease, diabetes, and cancer. Previously, risk assessments relied mainly on demographic, lifestyle, and clinical metrics. Now, the integration of PRSs and gut microbiome analysis into risk models promises to improve predictive accuracy beyond traditional factors. PRSs provide a cost-effective genetic predisposition metric, while the gut microbiome adds a novel dimension to understanding disease risk. This emerging approach necessitates further research to refine its accuracy and ensure its effectiveness across various populations and healthcare systems.
In a study published in Nature Mental Health, scientists from China and the United States have found that individuals suffering from chronic musculoskeletal pain (CMP) may face a higher high risk of brain aging.
Valter Longo, who wants to live to a healthy 120 or 130, sees the key to longevity in diet â legumes and fish â and faux fasting.
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhDDiscount Links: At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgartenUse Code: CâŠ
Recent observations show that some white dwarf stars suddenly stop cooling. Now, scientists propose a âfountian of youthâ mechanism that may explain how these stellar husks avoid death for billions of years.
Plasma exchange human trials.
TPE Treatment, is an FDA-approved treatment for many autoimmune diseases, shows age reversal identified by multiple biological clocks. It improved both physical strength and mental health in human clinical trial(unpublished data) presented by Dr. Kiprov.
TPE Treatment remove certain harmful substances circulating in plasma to nourish cellular habitat and support regenerative factors. A special machine separates the polluted plasma from blood cells. The aged, polluted plasma is discarded and replaced with clean, individualized, plasma-like replacement fluids, albumin, immunoglobins and other regeneration promoting factors. The new solution of freshly-cleaned blood is infused back to the body.
Reference Links:
https://link.springer.com/article/10âŠ
https://www.lifespan.io/news/plasma-dâŠ
https://pubmed.ncbi.nlm.nih.gov/34074âŠ
https://link.springer.com/article/10âŠ
More About Dr. Kiprov:
A time question and answer starting at 32:22 (5â6 years)
Is aging a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary OâReilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.
What is epigenetics? Discover the difference between genetics and epigenetics. We discuss whether aging is a disease and if there have been any changes in aging throughout the centuries. David breaks down the information theory of aging and how epigenetic inheritance works. Plus, Chuck tells us about some of the studies heâs reading and how behaviors during your lifetime can be epigenetically passed onto your children.
Could we someday cure death? What does aging look like in the broader animal kingdom? We look at aging from an evolutionary standpoint, restoring vision in blind mice, and what the length of your telomeres tells you. We break down conflicting information regarding diet and how to not just live longer but live younger, longer. What are the genes that control aging?
We break down what anti-aging medicine would look like and whether it would be affordable for everyday people. Learn about the worldâs oldest mice with the youngest eyes. We discuss the Yamanaka genes and how they can be utilized to turn back time on a cellular level. Is DNA destiny?
Researchers from the Broad Institute of MIT and Harvard, along with colleagues from Harvard Medical School and McLean Hospital, have identified remarkably consistent alterations in gene expression within the brains of individuals with schizophrenia and older adults. This discovery points to a shared biological foundation underlying the cognitive difficulties frequently observed in patients with schizophrenia and in aging populations.
In a study published in Nature, the team describes how they analyzed gene expression in more than a million individual cells from postmortem brain tissue from 191 people. They found that in individuals with schizophrenia and in older adults without schizophrenia, two brain cell types called astrocytes and neurons reduced their expression of genes that support the junctions between neurons called synapses, compared to healthy or younger people. They also discovered tightly synchronized gene expression changes in the two cell types: when neurons decreased the expression of certain genes related to synapses, astrocytes similarly changed expression of a distinct set of genes that support synapses.
The team called this coordinated set of changes the Synaptic Neuron and Astrocyte Program (SNAP). Even in healthy, young people, the expression of the SNAP genes always increased or decreased in a coordinated way in their neurons and astrocytes.