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The human trial of plasma dilution started in Russia last week. The lead researcher is checking how the biomarkers of aging will change in response to 110% plasma replacement during the therapy, and the difference between the group with albumin addition and without albumin. The trial is open to both Russian citizens and people from other countries. It is a hybrid model where part of the expenditures is paid by the volunteers, and part is provided by the patron of the research. This model allowed to get the trial started in record time — less than 9 months from conception to the start date.
The research group wants to test plasmapheresis in combination with other longevity therapies next to see if plasma dilution prior to the other therapy can enhance the results.
Are you interested in longevity news? Come over to https://youtube.com/x10show for more!
Does blood hold the secret to aging? That’s kind of what an ongoing clinical trial in Russia is trying to find out. Previous experiments carried out in aged mice suggest that plasma dilution has positive effects on cognition and neuroinflammation, and now scientists want to see if the procedure can positively impact humans too.
By the way, don’t forget our conference Ending Age-Related Diseases 2021 is coming soon! Follow this link to learn more and get your ticket:
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In this video, Drs Irina and Mike Conboy talk about their theory of why we age and introduce Neutral Blood Exchange, which came from their original parabiosis experiments documented in a 2005 paper.
Our guests today are Drs. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. their discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.
Papers mentioned in this video.
Plasma dilution improves cognition and attenuates neuroinflammation in old mice.
https://pubmed.ncbi.nlm.nih.gov/33191466/
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.
https://pubmed.ncbi.nlm.nih.gov/32474458/
Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
https://pubmed.ncbi.nlm.nih.gov/15716955/
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Audio Copyright Disclaimer:
The radar-like scan moves clockwise emanating from the center point to produce pitch. Light that is further from the center is heard as higher pitches while brighter light is louder. The X-rays are represented by a harsher sound, while the visible-light data sound smoother.
Credit: NASA/CXC/SAO/K.Arcand, SYSTEM Sounds.
Emotion regulation is an essential aspect of mental health and wellbeing. In fact, past studies have found associations between poor emotion regulation and several psychiatric disorders, including bipolar disorder, borderline personality disorder and complex post-traumatic stress disorder (PTSD).
During their everyday life, humans can regulate their negative emotions in different ways, most of which do not require any conscious cognitive engagement. For instance, they might take a bath, step outside for fresh air or listen to music.
Researchers at Radboud University Nijmegen in The Netherlands, the Norwegian University of Science and Technology (NTNU), and University Hospital Aachen, Germany have recently carried out a study aimed at investigating the effects of a short-term musical training on implicit emotion regulation. Their paper, published in BMC Neuroscience, specifically examined whether musical training helped people to reduce the negative emotions elicited by unpleasant or disgusting odors.
A new music creation plug-in uses machine intelligence to compose songs on the fly that match the visual tone and rhythm of creators’ videos.
These spring-loaded screws turn your entire drywall into a sound deadening structure that can reduce perceived noise levels by nearly half. They’re pricey for screws, says the Swedish scientist behind them, but very cheap for sound insulation. Known as the Revolutionary Sound Absorbing Screw (or the Sound Screw for short), the device was created by a team at Malmö University, led by senior lecturer Håkan Wernersson. It consists of a threaded section at the bottom, a coil spring in the middle, and a section with a flat head at the top.
Nobody likes hearing their neighbors’ music, TV shows or loud conversations. Soundproof wall materials, however, can be quite thick and expensive. Swedish scientists have developed a thinner, less costly alternative, in the form of a spring-loaded sound-damping screw.
Known as the Revolutionary Sound Absorbing Screw (or the Sound Screw for short), the device was created by a team at Malmö University, led by senior lecturer Håkan Wernersson. It consists of a threaded section at the bottom, a coil spring in the middle, and a section with a flat head at the top.
The screw is inserted into a hole drilled through a drywall panel and into the underlying wooden joist. It is then turned until its threaded section is all the way into the wood, and its head is sitting flush against the outside surface of the drywall. The spring forms of a gap of a few millimeters between the joist and the drywall’s underside.
The Gist: They think they can start wider human trials soon which would last 2 years then have a product in 3 to 4 years.
In this video, Drs Irina and Mike Conboy talk how TPE, therapeutic plasma exchange is already available as an FDA approved procedure and the plans to extend the usage to include more age related diseases. We also discuss the company that they have formed IMU
Our guests today are Drs. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. their discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.
Papers mentioned in this video.
Plasma dilution improves cognition and attenuates neuroinflammation in old mice.
https://pubmed.ncbi.nlm.nih.gov/33191466/
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.
https://pubmed.ncbi.nlm.nih.gov/32474458/
Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
https://pubmed.ncbi.nlm.nih.gov/15716955/
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In this video, Drs Irina and Mike Conboy talk about the procedure of Neutral Blood Exchange. How it is done and how much blood of the blood is exchanged.
Our guests today are Drs. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. their discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.
Papers mentioned in this video.
Plasma dilution improves cognition and attenuates neuroinflammation in old mice.
https://pubmed.ncbi.nlm.nih.gov/33191466/
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.
https://pubmed.ncbi.nlm.nih.gov/32474458/
Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
https://pubmed.ncbi.nlm.nih.gov/15716955/
************************************************************
Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation.
Audio Copyright Disclaimer:
Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to legal@wevideo.com.
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