Nanosafety researchers at the Harvard T.H. Chan School of Public Health have developed a new intervention to fight infectious disease by more effectively disinfecting the air around us, our food, our hands, and whatever else harbors the microbes that make us sick.
They used a nano-enabled platform developed at the center to create and deliver tiny, aerosolized water nonodroplets containing non-toxic, nature-inspired disinfectants wherever desired.
Circa 2016 could cure viruses in no time.
When you get right down to it, developing vaccines is about data and luck. Scientists start with a set of variables—what drugs a virus responds to, how effectively, and for whom—and then it’s a whole lot of trial and error until they stumble upon a cure.
One of the most exciting possibilities in medical research right now is how technology like machine learning could help researchers rapidly process those enormous sets of data, more quickly leading to cures. This is already starting to happen: In a study published Wednesday in the journal Macromolecules, researchers from IBM and Singapore’s Institute of Bioengineering and Nanotechnology reveal a breakthrough that could help prevent deadly virus infections. With the help of IBM super computer Watson, they hope their finding will soon make its way into vaccines.
Michigan State University and Stanford University scientists have invented a nanoparticle that eats away—from the inside out—portions of plaques that cause heart attacks.
Bryan Smith, associate professor of biomedical engineering at MSU, and a team of scientists created a “Trojan Horse” nanoparticle that can be directed to eat debris, reducing and stabilizing plaque. The discovery could be a potential treatment for atherosclerosis, a leading cause of death in the United States.
The results, published in the current issue of Nature Nanotechnology, showcases the nanoparticle that homes in on atherosclerotic plaque due to its high selectivity to a particular immune cell type—monocytes and macrophages. Once inside the macrophages in those plaques, it delivers a drug agent that stimulates the cell to engulf and eat cellular debris. Basically, it removes the diseased/dead cells in the plaque core. By reinvigorating the macrophages, plaque size is reduced and stabilized.
We’re still a long way from Star Trek-style tricorders that can instantly diagnose disease, but medical startup Nanox is hoping to bring a little of the 24th century to a hospital near you. The company has unveiled a new low-cost X-ray scanner called the Nanox. Arc. It hopes to deploy 15,000 units in the coming years, with the aim of making medical scans more available and affordable.
Nanox was founded in 2016 by Japanese venture capitalist Hitoshi Masuya in partnership with Sony. The consumer electronics giant later bowed out, but Masuya joined forces with current CEO Ran Poliakine to split the company’s operations between Israel and Japan. Nanox has now raised a total of $55 million to fund the development of Nanox. Arc, which supposedly offers the same capabilities of traditional X-ray machines with a much smaller footprint and lower operating costs.
Current X-ray machinery is bulky, requiring arrays of rotating tubes with superheated filaments that produce electron clouds. When moved near a metal anode, the filament produces the X-rays needed for imaging. These giant analog contraptions require heavy shielding to keep patients safe, and they use a lot of power. There’s also a substantial upfront cost that can run $2–3 million. The Nanox. Arc, on the other hand, uses silicon micro-electromechanical systems (MEMs) in the form of more than 100 million molybdenum nano-cones that generate electrons.
A dumbbell-shaped nanoparticle powered just by the force and torque of light has become the world’s fastest-spinning object.
Scientists at Purdue University created the object, which revolves at 300 billion revolutions per minute. Or, put another way, half a million times faster than a dentist’s drill.
In addition, the silica nanoparticle can serve as the world’s most sensitive torque detector, which researchers hope will be used to measure the friction created by quantum effects.
#biophotonics #photonics
ONNA, Japan, Jan. 13, 2020 — Scientists at the Okinawa Institute of Science and Technology (OIST) Graduate University have developed a light-based device that can act as a biosensor, detecting biological substances in materials, such as harmful pathogens in food. The scientists said that their tool, an optical microresonator, is 280× more sensitive than current industry-standard biosensors, which can detect only cumulative effects of groups of particles, not individual molecules.
To detect the quantum friction of empty space, scientists are going for a spin.
A twirling nanoparticle, suspended in a laser beam inside of a vacuum, can measure tiny twisting forces, making it the most sensitive detector of torque yet created. Researchers say the device could one day detect an elusive quantum effect called vacuum friction.
The suspended nanoparticle can spin more than 300 billion times a minute. “This is the fastest human-made rotor in the world,” says physicist Tongcang Li of Purdue University in West Lafayette, Ind.
Drastic miniaturization of electronics and ingression of next-generation nanomaterials into space technology have provoked a renaissance in interplanetary flights and near-Earth space exploration using small unmanned satellites and systems. As the next stage, the NASA’s 2015 Nanotechnology Roadmap initiative called for new design paradigms that integrate nanotechnology and conceptually new materials to build advanced, deep-space-capable, adaptive spacecraft. This review examines the cutting edge and discusses the opportunities for integration of nanomaterials into the most advanced types of electric propulsion devices that take advantage of their unique features and boost their efficiency and service life. Finally, we propose a concept of an adaptive thruster.
Interesting research paper on a new nanobot technology. I’m watching for ways in which suitable substrates for mind uploading can be constructed, and DNA self-guided assembly has potential.
Here are some excerpts and a weblink to the paper:
“…Chemical approaches have opened synthetic routes to build dynamic materials from scratch using chemical reactions, ultimately allowing flexibility in design…”
… As a realization of this concept, we engineered a mechanism termed DASH—DNA-based Assembly and Synthesis of Hierarchical materials—providing a mesoscale approach to create dynamic materials from biomolecular building blocks using artificial metabolism. DASH was developed on the basis of nanotechnology that uses DNA as a generic material ranging from nanostructures to hydrogels, for enzymatic substrates, and as linkers between nanoparticles…”
“…Next, to illustrate the potential uses of self-generated materials, we created various hybrid functional materials from the DASH patterns. The DASH patterns served as a versatile mesoscale scaffold for a diverse range of functional nanomaterials beyond DNA, ranging from proteins to inorganic nanoparticles, such as avidin, quantum dots, and DNA-conjugated gold nanoparticles (AuNPs) (Fig. 4D, figs. S37 and S38, and Supplementary Text). The generated patterns were also rendered functional with catalytic activity when conjugated with enzymes (figs. S39 and S40 and Supplementary Text). We also showed that the DNA molecules within the DASH patterns retained the DNA’s genetic properties and that, in a cell-free fashion, the materials themselves successfully produced green fluorescent proteins (GFPs) by incorporating a reporter gene for sfGFP (Fig. 4E and figs. S9 and S41) (40). The protein production capability of the materials established the foundation for future cell-free production of proteins, including enzymes, in a spatiotemporally controlled manner.
…” Our implementation of the concept, DASH, successfully demonstrated various applications of the material. We succeeded in constructing machines from this novel dynamic biomaterial with emergent regeneration, locomotion, and racing behaviors by programming them as a series of FSAs. Bottom-up design based on bioengineering foundations without restrictions of life fundamentally allowed these active and programmable behaviors. It is not difficult to envision that the material could be integrated as a locomotive ele-ment in biomolecular machines and robots. The DASH patterns could be easily recognized by naked eyes or smartphones, which may lead to better detection technologies that are more feasible in point-of-care settings. DASH may also be used as a template for other materials, for example, to create dynamic waves of protein expression or nanoparticle assemblies. In addition, we envision that further expansion of artificial metabolism may be used for self-sustaining structural components and self-adapting substrates for chemical production pathways. Ultimately, our material may allow the construction of self-reproducing machines through the production of enzymes from generated materials that, in turn, reproduce the material. Our biomaterial powered by artificial metabolism is an important step toward the creation of “artificial” biological systems with dynamic, life-like capabilities.”…