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Category: neuroscience – Page 1,044

Transhumanist Zoltan Istvan becomes advisor at “Brain Space”! Welcome!

I recently become an advisor at Brain Space, a new #blockchain company creating a better system to deal with copyrights and patents. They have an ICO coming up here very soon. Here’s an article (with a video I did) with more info: https://medium.com/…/transhumanist-zoltan-istvan-becomes-ad… AND CHECK OUT THEIR WEBSITE: https://brain-space.io/

Zoltan Istvan, an American-Hungarian, began a solo, multi-year sailing journey around the world at the age of 21. His main cargo was 500 handpicked books, mostly classics. He’s explored over 100 countries — many as a journalist for the National Geographic Channel — writing, filming, and appearing in dozens of television stories, articles, and webcasts. His work has also been featured by The New York Times, Outside, Wired UK, Slate, Vice, San Francisco Chronicle, BBC Radio, CNN, CBS, RT, Fox News, the Travel Channel, and in much other media.

More about Zoltan at https://www.linkedin.com/in/zoltan-istvan-78aa2964/

Link to ICO: https://brain-space.io/

Link to the test version of copyright protection: https://deposit.brainspace.world/register

Gut bacteria may control movement

🤔👀

A new study puts a fresh spin on what it means to “go with your gut.” The findings, published in Nature, suggest that gut bacteria may control movement in fruit flies and identify the neurons involved in this response. The study was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

The How, Why, and Whether of Custom Digital Avatars That Live on After We Die

Imagine a digital avatar of ourselves living on after we die. They could help comfort our loved ones, and they could also preserve expertise and experience. There’s some benefits, but it’s still questionable if this is comforting, or just creepy.

A digital afterlife may soon be within reach, but it might not be for your benefit.

The reams of data we’re creating could soon make it possible to create digital avatars that live on after we die, aimed at comforting our loved ones or sharing our experience with future generations.

That may seem like a disappointing downgrade from the vision promised by the more optimistic futurists, where we upload our consciousness to the cloud and live forever in machines. But it might be a realistic possibility in the not-too-distant future—and the first steps have already been taken.

RbAp48 And Osteocalcin Play A Crucial Role In Age-related Memory Loss

Protein RbAp48 works with osteocalcin to preserve memory in old age.

In a recent open-access study, scientists at Columbia University have demonstrated that a protein known as RbAp48 crucially interacts with osteocalcin to help preserve memory. The protein, which is present in mice as well as people, declines with age, contributing to age-related memory loss [1].

Abstract

Precisely deciphering the molecular mechanisms of age-related memory loss is crucial to create appropriate therapeutic interventions. We have previously shown that the histone-binding protein RbAp48/Rbbp4 is a molecular determinant of Age-Related Memory Loss. By exploring how this protein regulates the genomic landscape of the hippocampal circuit, we find that RbAp48 controls the expression of BDNF and GPR158 proteins, both critical components of osteocalcin (OCN) signaling in the mouse hippocampus. We show that inhibition of RbAp48 in the hippocampal formation inhibits OCN’s beneficial functions in cognition and causes deficits in discrimination memory. In turn, disruption of OCN/GPR158 signaling leads to the downregulation of RbAp48 protein, mimicking the discrimination memory deficits observed in the aged hippocampus. We also show that activation of the OCN/GPR158 pathway increases the expression of RbAp48 in the aged dentate gyrus and rescues age-related memory loss.

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