Scientists studied s-KL Klotho protein therapy in aging mice, showing potential to improve muscle, bone, and memory health.
Category: neuroscience – Page 37
Deep brain regions link all senses to consciousness, study finds
A Yale-led study shows that the senses stimulate a region of the brain that controls consciousness—a finding that might inform treatment for disorders related to attention, arousal, and more.
Humans perceive and navigate the world around us with the help of our five senses: sight, hearing, touch, taste and smell. And while scientists have long known that these different senses activate different parts of the brain, a new Yale-led study indicates that multiple senses all stimulate a critical region deep in the brain that controls consciousness.
The study, published in the journal NeuroImage, sheds new light on how sensory perception works in the brain and may fuel the development of therapies to treat disorders involving attention, arousal, and consciousness.
Psilocybin better preserves depressed patients’ emotional response to music than standard drug, study finds
Depression is among the most widespread mental health disorders worldwide, typically characterized by persistent feelings of sadness, a lack of interest in daily activities and dysregulated sleep and/or eating habits. There are now a wide range of pharmacological treatments for depression, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants and atypical antidepressants.
In recent years, some research groups have been exploring the potential of alternative treatments for depression that rely on psychedelic compounds, such as psilocybin. Psilocybin is a compound naturally found in more than 100 species of mushrooms, which can influence the mood and perceptions of those who ingest it.
Researchers at Imperial College London’s Center for Psychedelic Research recently carried out a study aimed at better understanding the effects of psilocybin treatment on the processing of music and the experience of emotions, comparing them to those of escitalopram, a widely used SSRI.
Abstract: For several years, researchers have known that hyperactivity of a subset of neurons located in the hypothalamus, called AgRP neurons, is common in mice with diabetes
“These neurons are playing an outsized role in hyperglycemia and type 2 diabetes,” said UW Medicine endocrinologist Dr. Michael Schwartz, corresponding author of the paper.
To determine if these neurons contribute to elevated blood sugar in diabetic mice, researchers employed a widely used viral genetics approach to make AgRP neurons express tetanus toxin, which prevents the neurons from communicating with other neurons.
Unexpectedly, this intervention normalized high blood sugar for months, despite having no effect on body weight or food consumption.
Conventional wisdom is that diabetes, particularly type 2 diabetes, stems from a combination of genetic predisposition and lifestyle factors, including obesity, lack of physical activity and poor diet. This mix of factors leads to insulin resistance or insufficient insulin production.
Until now, scientists have traditionally thought the brain doesn’t play a role in type 2 diabetes, according to Schwartz.
The paper challenges this and is a “departure from the conventional wisdom of what causes diabetes,” he said.
The new findings align with studies published by the same scientists showing that injection of a peptide called FGF1 directly into the brain also causes diabetes remission in mice. This effect was subsequently shown to involve sustained inhibition of AgRP neurons.
