People with shorter telomeres — the protective caps at the ends of their chromosomes — may have a higher risk of developing age-related brain diseases such as stroke, dementia, and late-life depression (typically diagnosed at age 60 or older). This finding comes from a preliminary study set to be presented at the American Stroke Association’s International Stroke Conference 2025, a leading global event for stroke and brain health research, taking place in Los Angeles from February 5–7, 2025.
Telomere length in white blood cells (leukocytes), known as leukocyte telomere length, is a well-established marker of biological aging. As people age, telomeres naturally shorten, reducing their ability to protect chromosomes, which accelerates cellular aging and increases vulnerability to age-related diseases. While telomere length is partly determined by genetics, ancestry, and gender, it is also influenced by lifestyle factors and environmental stressors such as diet, exercise, and pollution.
Dr James Cooke, PhD trained is a neuroscientist, speaker, and writer. He holds three degrees from Oxford University (a PhD and Masters in Neuroscience & a BA in Experimental Psychology). He has conducted scientific research for over a decade at institutions such as Oxford University, University of California, Berkeley, University College London, Trinity College Dublin, and Riken Brain Sciences Institute in Tokyo. James is the author of The Dawn of Mind: How Matter Became Conscious and Alive (2024), which synthesizes science and spiritual insight to offer a radical solution to the Hard Problem of Consciousness. He is the founder of the \.
Dr. Simon Stringer. Obtained his Ph.D in mathematical state space control theory and has been a Senior Research Fellow at Oxford University for over 27 years. Simon is the director of the Oxford Centre for Theoretical Neuroscience and Artificial Intelligence, which is based within the Oxford University Department of Experimental Psychology. His department covers vision, spatial processing, motor function, language and consciousness — in particular — how the primate visual system learns to make sense of complex natural scenes. Dr. Stringers laboratory houses a team of theoreticians, who are developing computer models of a range of different aspects of brain function. Simon’s lab is investigating the neural and synaptic dynamics that underpin brain function. An important matter here is the The feature-binding problem which concerns how the visual system represents the hierarchical relationships between features. the visual system must represent hierarchical binding relations across the entire visual field at every spatial scale and level in the hierarchy of visual primitives.
We discuss the emergence of self-organised behaviour, complex information processing, invariant sensory representations and hierarchical feature binding which emerges when you build biologically plausible neural networks with temporal spiking dynamics.
00:00:00 Tim Intro. 00:09:31 Show kickoff. 00:14:37 Hierarchical Feature binding and timing of action potentials. 00:30:16 Hebb to Spike-timing-dependent plasticity (STDP) 00:35:27 Encoding of shape primitives. 00:38:50 Is imagination working in the same place in the brain. 00:41:12 Compare to supervised CNNs. 00:45:59 Speech recognition, motor system, learning mazes. 00:49:28 How practical are these spiking NNs. 00:50:19 Why simulate the human brain. 00:52:46 How much computational power do you gain from differential timings. 00:55:08 Adversarial inputs. 00:59:41 Generative / causal component needed? 01:01:46 Modalities of processing i.e. language. 01:03:42 Understanding. 01:04:37 Human hardware. 01:06:19 Roadmap of NNs? 01:10:36 Intepretability methods for these new models. 01:13:03 Won’t GPT just scale and do this anyway? 01:15:51 What about trace learning and transformation learning. 01:18:50 Categories of invariance. 01:19:47 Biological plausibility.
Pod version: https://anchor.fm/machinelearningstre… https://en.wikipedia.org/wiki/Simon_S… / simon-stringer-a3b239b4 “A new approach to solving the feature-binding problem in primate vision” https://royalsocietypublishing.org/do… James B. Isbister, Akihiro Eguchi, Nasir Ahmad, Juan M. Galeazzi, Mark J. Buckley and Simon Stringer Simon’s department is looking for funding, please do get in touch with him if you can facilitate this. #machinelearning #neuroscience.
People with diabetes have a higher risk of developing Alzheimer’s disease (AD) raising a possible link between the cells that are disordered in diabetes—pancreatic β cells—and AD. A study reveals these cells may secrete neuroprotective factors.
An international research team led by the University of Göttingen has investigated the influence of the forces exerted by the Zagros Mountains in the Kurdistan region of Iraq on how much the surface of the Earth has bent over the last 20 million years. Their research has revealed that in the present day, deep below the Earth’s surface, the Neotethys oceanic plate—the ocean floor that used to be between the Arabian and Eurasian continents—is breaking off horizontally, with a tear progressively lengthening from southeast Turkey to northwest Iran.
Their findings show how the evolution of the Earth’s surface is controlled by processes deep within the planet’s interior. The research is published in the journal Solid Earth.
When two continents converge over millions of years, the oceanic floor between them slides to great depths beneath the continents. Eventually, the continents collide, and masses of rock from their edges are lifted up into towering mountain ranges. Over millions of years, the immense weight of these mountains causes the Earth’s surface around them to bend downward. Over time, sediments eroded from the mountains accumulate in this depression, forming plains such as Mesopotamia in the Middle East.
A research team from Japan has developed a unified model to scale the transitional pressure development in a one-dimensional flow. This achievement provides a better understanding of how pressure fields build up in the confined fluid system for various acceleration situations, which might be applicable to biomechanics-related impact problems, such as human brain injuries caused by physical contact.
Liquid is usually not considered compressible, except for when subjected to a high-speed flow or rapid acceleration. The latter case is known as the water hammer theory, which often occurs with a loud sound when a water faucet is suddenly closed.
In recent years, the onset of mild traumatic brain injury has been discussed in a similar context, meaning that better understanding of this issue is important in not only traditional engineering but also emerging biomechanics applications.
New research found that individuals with anorexia nervosa have elevated opioid neurotransmitter.
A neurotransmitter is a chemical substance that transmits signals across a synapse from one neuron to another in the nervous system. These chemicals play a crucial role in the functioning of the brain and body, influencing everything from mood, sleep, and learning to heart rate, anxiety, and fear. Common neurotransmitters include dopamine, serotonin, acetylcholine, and norepinephrine. They bind to specific receptors on the surface of neurons, triggering various physiological responses and allowing for the communication that underpins all neural activities. Imbalances in neurotransmitter levels can lead to neurological disorders or mental health issues, making them a central focus of study in both medicine and psychology.
A study by cognitive neuroscientists at SISSA investigated how the human brain processes space and time, uncovering that these two types of information are only partially connected.
Imagine a swarm of fireflies flickering in the night. How does the human brain process and integrate information about both their duration and spatial position to form a coherent visual experience? This question was the focus of research by Valeria Centanino, Gianfranco Fortunato, and Domenica Bueti from SISSA’s Cognitive Neuroscience group, published in Nature Communications
<em> Nature Communications </em> is an open-access, peer-reviewed journal that publishes high-quality research from all areas of the natural sciences, including physics, chemistry, Earth sciences, and biology. The journal is part of the Nature Publishing Group and was launched in 2010. “Nature Communications” aims to facilitate the rapid dissemination of important research findings and to foster multidisciplinary collaboration and communication among scientists.
