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Category: neuroscience – Page 57

Treating postoperative delirium as preventable ‘acute brain failure’: Low-cost interventions could have major impact

A new large-scale study spotlights postoperative delirium as a preventable and high-impact complication which is driven by patient frailty and surgical stress—and one that can be addressed through low-cost, evidence-based interventions.

The findings, which appear in JAMA Network Open, provide a call to action for clinicians, health systems, patients, and families to prioritize brain health throughout perioperative care.

“Postoperative delirium isn’t a minor complication—it’s analogous to acute brain failure, a medical emergency that should be recognized and addressed,” said Laurent Glance, MD, a professor of Anesthesiology and Perioperative Medicine at the University of Rochester Medical Center (URMC) and senior author of the study.

Psilocybin treatment extends cellular lifespan and improves survival of aged mice

Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged mice, suggesting that psilocybin may be a potent geroprotective agent.

Kato, K., Kleinhenz, J.M., Shin, YJ. et al. Psilocybin treatment extends cellular lifespan and improves survival of aged mice. npj Aging 11, 55 (2025). https://doi.org/10.1038/s41514-025-00244-x.

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Late eating is associated with impaired glucose metabolism

Our metabolic processes differ depending on the time of day and many of them are more active in the morning than in the evening. Although studies show that eating late in the day is associated with an increased risk of obesity and cardiovascular diseases, little is known about how the time we eat affects glucose metabolism and to what extent this is genetically defined.

Prof. Olga Ramich from the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE) and her team recently investigated this using data from a twin cohort from 2009-10. Their article was published in the journal eBioMedicine.

The is a hierarchically structured 24-hour time control system in the body that regulates behavior and metabolism via a central clock in the brain and peripheral clocks in organs such as the liver or pancreas. As a result, our differ depending on the time when we eat, which leads to diurnal fluctuations in glucose metabolism and the release of hormones after a meal.

Quantum enhancement discovery could improve medical technologies

Technologies such as biomedical imaging and spectroscopy could be enhanced by a discovery in research that involved several institutions, including the University of Glasgow. Scientists have found that two-photon processes, which have applications in the study of Alzheimer’s disease and other nervous system disorders, can be strengthened by quantum light at far higher levels than previously thought possible.

The processes normally require high-intensity light but this can cause samples to be damaged or bleached.

It was suggested many years ago—and has since been demonstrated—that entangled could overcome this limitation. However, it has been widely believed that this quantum enhancement only survives for very faint light, raising doubts about the usefulness of the approach.

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