A new study is shedding light on how stimulating the right bits of the brain can produce dramaticâand seemingly permanentâimprovements in the ability of paralysed patients to walk again https://econ.st/3DfZk5L
Photo: NeuroRestore / EPFL 2024
Implanted electrodes allowed one man to climb stairs unaided.
Thirteen proteins linked to brain aging in humans are identified in a Nature Aging paper. Changes in the concentrations of these blood proteins may peak at 57, 70, and 78 years old in humans, and suggest that these ages may be important for potential interventions in the brain aging process.
It is estimated that by 2050 the number of individuals aged 65 years and over will exceed 1.5 billion globally, highlighting the need for a deeper understanding of the aging processâparticularly in relation to the brain.
The prevalence of neurodegenerative disorders, such as dementia, is known to increase with aging; however, effective therapies are still limited. The early identification of and intervention in brain aging could help us to prevent such disorders.
New research suggests Alzheimerâs drugs may improve cognition by increasing AÎČ42 levels rather than just reducing plaques, challenging the amyloid cascade hypothesis and pointing to new therapeutic strategies focused on restoring soluble AÎČ42 to maintain brain health.
Summary: Human number cognition may be rooted in the putamen, a deep brain structure traditionally associated with movement rather than abstract thought. Neurosurgery patients demonstrated activity in this area while processing numbers as symbols, words, and concepts, suggesting that numerical understanding emerged early in evolution.
Researchers also observed activity in expected areas like the parietal lobe, highlighting how different brain regions collaborate in number processing. These findings could improve surgical outcomes by protecting areas crucial for number cognition and open pathways to enhancing math learning through targeted interventions.
Summary: Research reveals that people with high blood pressure who also sleep less than six hours per night face increased risks of brain injury, accelerated brain aging, and impaired executive function. The study assessed 682 participants from the Framingham Heart Study, analyzing sleep patterns, blood pressure, cognitive performance, and brain MRIs.
These risks were not present in individuals with normal blood pressure, highlighting a concerning interaction between sleep deprivation and hypertension. Researchers suggest treating sleep problems and hypertension as potential interventions to protect brain health and delay cognitive decline.
Researchers at The Hospital for Sick Children (SickKids) have uncovered that stress changes how our brain encodes and retrieves aversive memories, and discovered a promising new way to restore appropriate memory specificity in people with post-traumatic stress disorder (PTSD).
If you stumble during a presentation, you might feel stressed the next time you have to present because your brain associates your next presentation with that one poor and aversive experience. This type of stress is tied to one memory.
But stress from traumatic events like violence or generalized anxiety disorder can spread far beyond the original event, known as stress-induced aversive memory generalization, where fireworks or car backfires can trigger seemingly unrelated fearful memories and derail your entire day. In the case of PTSD, it can cause much greater negative consequences.
A Novel 14mer Peptide Inhibits Autophagic Flux via Selective Activation of the mTORC1 Signalling Pathway: Implications for Alzheimerâs Disease
Posted in biotech/medical, life extension, neuroscience | Leave a Comment on A Novel 14mer Peptide Inhibits Autophagic Flux via Selective Activation of the mTORC1 Signalling Pathway: Implications for Alzheimerâs Disease
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đ§đ»âđŹ By Ms. Cloe GarcĂa Porta, Dr. Kashif Mahfooz, Mr. Joanna Komorowska, Dr. Sara Garcia-Rates and Dr. Susan Greenfield.
During development, a 14mer peptide, T14, modulates cell growth via the α-7 nicotinic acetylcholine receptor (α7 nAChR). However, this process could become excitotoxic in the context of the adult brain, leading to pathologies such as Alzheimerâs disease (AD). Recent work shows that T14 acts selectively via the mammalian target of rapamycin complex 1 (mTORC1). This pathway is essential for normal development but is overactive in AD. The triggering of mTORC1 has also been associated with the suppression of autophagy, commonly observed in ageing and neurodegeneration. We therefore investigated the relationship between T14 and autophagic flux in tissue cultures, mouse brain slices, and human Alzheimerâs disease hippocampus.
A groundbreaking study has used patient-derived stem cells to recreate a rare genetic form of autism in the lab.
A new way of mapping activity and connections between different regions of the brain has revealed fresh insights into how higher order functions like language, thought and attention, are organized.
Traditional models of human brain activity represent interactions in pairs between two different brain regions. This is because modeling methods have not developed sufficiently to describe more complex interactions between multiple regions.
A new approach, developed by researchers at the University of Birmingham is capable of taking signals measured through neuroimaging, and creating accurate models from these to show how different brain regions are contributing to specific functions and behaviors. The results are published in Nature Communications.