Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: neuroscience – Page 92

Neurological disorders as a window into cognitive function

Brain injury, disease and subsequent interventions can alter behaviour, providing a unique opportunity to study cognitive processes. This Collection seeks to bridge the gap between neurologists and neurosurgeons studying clinical disorders and neuroscientists studying neural processes underlying typical cognition.

The editors at Nature Communications, Communications Biology and Scientific Reports therefore invite original research articles examining neural mechanisms underlying cognitive functions in people affected by neurological conditions. This call for papers includes but is not limited to studies in patients with epilepsy, brain tumours, stroke, neuropsychiatric disorders, neurodegenerative disease or traumatic brain injury using brain stimulation and recording techniques and/or neuroimaging that offer new insights into the mechanisms behind cognitive processes. We also encourage submissions aiming to develop best practices and reporting of these studies. Preclinical work is not within scope for this collection.

This is a cross-journal Collection across Nature Communications, Communications Biology and Scientific Reports. Please see the relevant journal webpages to check which article types the journals consider.

Scientists Just Found the Secret Difference Between Human and Primate Brains

Researchers discovered uniquely human neuroanatomical features in a study comparing human brains to macaque and chimpanzee brains.

A groundbreaking study reveals that what makes humans unique isn’t just intelligence but also emotional and social cognition. Comparing brain scans of humans, chimpanzees, and macaques, researchers found that key brain connections related to emotions and social interactions are distinctly human, highlighting the deep-rooted role of relationships in human evolution.

What makes the human brain unique?

Scientists Uncover a Hidden Brain Plumbing System That Restores Memory

Aging brains may struggle to clear out waste, contributing to memory loss and diseases like Alzheimer’s. But researchers have now found that improving the brain’s waste-draining vessels in old mice actually boosted their memory. Rather than targeting the brain directly, which is tricky due to the

Lowering bioenergetic age may help fend off Alzheimer’s

The researchers turned to a group of molecules called acylcarnitines, which are associated with declining cognition and breaking down or metabolizing fats and proteins for energy. To test if high acylcarnitine levels in the blood could predict who’s at risk of developing Alzheimer’s, the researchers used data from a large-scale study called the Alzheimer’s Disease Neuroimaging Initiative.

“It was fascinating,” the author said. “Dividing research participants into groups based on their specific acylcarnitine levels highlighted people with more severe Alzheimer’s disease and others with fewer symptoms.” This led the researchers to define a bioenergetic clock based on acylcarnitines—how old a person’s metabolism acts, compared to actual age. Higher bioenergetic age is linked to higher acylcarnitine levels, worsened Alzheimer’s pathology, cognitive decline and brain atrophy.

The researchers also quantified cognitive decline using a common test called the mini-mental state examination, on which a score below 24 out of 30 points indicates impairment. They found that people with low acylcarnitine levels to begin with declined more slowly, losing about 0.5 points less per year than people with high acylcarnitine levels. The benefit is on par with the Alzheimer’s drug lecanemab.

To some degree, a person’s bioenergetic clock ticks forward at a rate determined by their genetics, but having a healthy lifestyle—for example, eating a plant-based diet and exercising —can help keep acylcarnitine levels low, which means a younger bioenergetic age, the author explained.

They went on to identify a subgroup of participants, about 30% of the Alzheimer’s Disease Neuroimaging Initiative, with older bioenergetic age but favorable genetic background. These individuals may benefit more from early lifestyle interventions designed to decrease their bioenergetic age and potentially delay or prevent the onset of Alzheimer’s.

Moving forward, the senior author hopes to home in on the lifestyle interventions most effective for lowering bioenergetic age. For example, eating a low-carb diet may help maintain metabolic health, but just how low would carbohydrate consumption have to be for a person to see benefits?

Continue reading “Lowering bioenergetic age may help fend off Alzheimer’s” | >

Boosting brain’s waste removal system improves memory in old mice

As aging bodies decline, the brain loses the ability to cleanse itself of waste, a scenario that scientists think could be contributing to neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease, among others.

Now, researchers at Washington University School of Medicine in St. Louis report they have found a way around that problem by targeting the network of vessels that drain waste from the brain. Rejuvenating those vessels, they have shown, improves memory in .

The study, published online in the journal Cell, lays the groundwork to develop therapies for age-related that overcome the challenges faced by conventional medications that struggle to pass through the to reach the brain.