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Category: neuroscience – Page 993

When tweaking its architecture, the adult brain works like a sculptor—starting with more than it needs so it can carve away the excess to achieve the perfect design. That’s the conclusion of a new study that tracked developing cells in an adult mouse brain in real time.

New began with a period of overgrowth, sending out a plethora of neuronal branches, before the brain pruned back the connections. The observation, described May 2, 2016 in Nature Neuroscience, suggests that new cells in the have more in common with those in the embryonic brain than scientists previously thought and could have implications for understanding diseases including autism, intellectual disabilities and schizophrenia.

“We were surprised by the extent of the pruning we saw,” says senior author Rusty Gage, a professor in Salk’s Laboratory of Genetics and holder of the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease.

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A new analysis indicates that a type of psychotherapy delivered by videoconference may help prevent some of the long-term memory issues caused by chemotherapy. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings point to a noninvasive way to help cancer survivors manage some of the negative effects of their treatment.

It’s estimated that approximately half of cancer patients who receive chemotherapy develop long-lasting changes in memory function such as trouble remembering conversational content or steps in a task. While the memory problems tend to be mild, they diminish quality of life in areas of job performance and family and social life well beyond cancer treatment. The causes of this problem and reasons why it does not affect every survivor remain unknown, and there is currently limited research on treatments for it.

A team led by Robert Ferguson, PhD, who is currently at the University of Pittsburgh Cancer Institute but was at the Eastern Maine Medical Center and Lafayette Family Cancer Center in Bangor, Maine, while conducting this research, developed a cognitive-behavioral therapy called “Memory and Attention Adaptation Training” (MAAT), which helps cancer survivors to increase awareness of situations where memory problems can arise and to develop skills to either prevent memory failure or to compensate for memory dysfunction.

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Military’s new Mission Impossible style messaging.

The U.S. military needs new messaging technology that’s ultra-secure and self-destructs. Sound familiar?

Think SnapChat. That’s an important part of what the Defense Advanced Research Projects Agency (DARPA) is aiming to do via a request for proposals posted on a DOD Web page. In Phase III of the project, DARPA says it requires “a secure messaging system that can provide… one time eyes only messages,” among a host of other features. Similarly, SnapChat allows a message to be viewed for a short length of time (1 to 10 seconds) before it becomes inaccessible, the primary reason it has become such a popular messaging platform.

Beyond this, the larger objective for the military is to meet a “critical DoD need to develop a secure messaging and transaction platform.” The DARPA request for proposals is aimed at building a messaging platform that the military could use for secure communication ranging from procurement to intelligence.

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Neurons created from chemically induced neural stem cells. The cells were created from skin cells that were reprogrammed into neural stem cells using a cocktail of only nine chemicals. This is the first time cellular reprogramming has been accomplished without adding external genes to the cells. (credit: Mingliang Zhang, PhD, Gladstone Institutes)

Scientists at the Gladstone Institutes have used chemicals to transform skin cells into heart cells and brain cells, instead of adding external genes — making this accomplishment a breakthrough, according to the scientists.

The research lays the groundwork for one day being able to regenerate lost or damaged cells directly with pharmaceutical drugs — a more efficient and reliable method to reprogram cells and one that avoids medical concerns surrounding genetic engineering.

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New keys unlock how words are stored in our brains.

Researchers have created a new map of the human brain which shows where we organize words depending on their meaning—and it could help us read minds more accurately than ever.

Scientists from the University of California, Berkeley, have published an interactive version of the map online. It allows you to explore the whole brain, clicking around to see where different types of words—from social and spatial, to violent and visual—are stored.

The team constructed the maps by playing seven different participants a two-hour chunk of The Moth Radio Hour while scanning their brains using functional MRI. The brain scans showed how the oxygen levels in blood across the brain changed, and this data was then used as a measure of how active a particular part of the brain was.

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What if a map of the brain could help us decode people’s inner thoughts?

Scientists at the University of California, Berkeley, have taken a step in that direction by building a “semantic atlas” that shows in vivid colors and multiple dimensions how the organizes language. The atlas identifies brain areas that respond to words that have similar meanings.

The findings, to be published April 28, 2016 in the journal Nature, are based on a brain imaging study that recorded neural activity while study volunteers listened to stories from the “Moth Radio Hour.” They show that at least one-third of the brain’s cerebral cortex, including areas dedicated to high-level cognition, is involved in language processing.

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