Lifeboat Foundation

Pain is a complex, multifaceted experience shaped by various factors beyond physical sensation, such as a person’s mindset and their expectations of pain. The placebo effect, the tendency for a person’s symptoms to improve in response to inactive treatment, is a well-known example of how expectations can significantly alter a person’s experience. Mindfulness meditation, which has been used for pain management in various cultures for centuries, has long been thought to work by activating the placebo response. However, scientists have now shown that this is not the case.

A new study, published in Biological Psychiatry, has revealed that mindfulness meditation engages distinct brain mechanisms to reduce pain compared to those of the placebo response. The study, conducted by researchers at University of California San Diego School of Medicine, used advanced brain imaging techniques to compare the pain-reducing effects of mindfulness meditation, a placebo cream and a “sham” mindfulness meditation in healthy participants.

The study found that mindfulness meditation produced significant reductions in pain intensity and pain unpleasantness ratings, and also reduced brain activity patterns associated with pain and negative emotions. In contrast, the placebo cream only reduced the brain activity pattern associated with the placebo effect, without affecting the person’s underlying experience of pain.

Across all species, critical skills are passed on from parents to offspring through communication. Researchers at the University Hospital Bonn (UKB) and the Researchers at the University of Bonn showed that effective communication relies on how both the sender and receiver represent information. Their study reveals how this process underlies training efficacy and task performance. Their results have been published in the journal Nature Communications.

Communication—be it through sounds, smells or movements—is crucial for survival. Its social aspect is fundamental to cognition, as our task descriptions in the brain are shaped not only by sensory experiences, but also by the information communicated to us.

“We know from our everyday lives that social communication is essential to our learning abilities in the real world, which is summed up by the saying ‘teaching is learning for the second time,” says Prof. Tatjana Tchumatchenko, from the Institute of Experimental Epileptology and Cognition Research at the UKB and member of the Transdisciplinary Research Area (TRA) “Modelling” at the University of Bonn.

Tiny robots much smaller than blood cells could deliver clot-forming drugs where they’re needed most, a study in rabbits suggests. The tech has yet to be tested in humans.

Extracellular vesicles (EVs) or exosomes are nanosized extracellular particles that contain proteins, DNA, non-coding RNA (ncRNA) and other molecules, which are widely present in biofluids throughout the body. As a key mediator of intercellular communication, EVs transfer their cargoes to target cells and activate signaling transduction. Increasing evidence shows that ncRNA is involved in a variety of pathological and physiological processes through various pathways, particularly the inflammatory response. Macrophage, one of the body’s “gatekeepers”, plays a crucial role in inflammatory reactions. Generally, macrophages can be classified as pro-inflammatory type (M1) or anti-inflammatory type (M2) upon their phenotypes, a phenomenon termed macrophage polarization.

Researchers have discovered that DNA methylation is crucial for reprogramming astrocytes into stem cells in the adult mouse brain, especially after ischemic injury, with potential implications for regenerative medicine.

Some of our closest invertebrate cousins, like this Acorn worm, have the ability to perfectly regenerate any part of their body that’s cut off — including the head and nervous system. Humans have most of the same genes, so scientists are trying to work out whether human regeneration is possible, too.

Regeneration – now that’d be a nice superpower to have. Injure an arm? Chop it off and wait for it to grow back. Dicky knee? Ingrown toenail? Lop off your leg and get two for one!

It sounds ridiculous, but there’s a growing number of scientists that believe body part regeneration is not only possible, but achievable in humans. After all, not only are there plenty of animals that can do it, we can do it ourselves for our skin, nails, and bits of other organs.

The Internet Archive has lost a major legal battle—in a decision that could have a significant impact on the future of internet history. Today, the US Court of Appeals for the Second Circuit ruled against the long-running digital archive, upholding an earlier ruling in Hachette v. Internet Archive that found that one of the Internet Archive’s book digitization projects violated copyright law.

Notably, the appeals court’s ruling rejects the Internet Archive’s argument that its lending practices were shielded by the fair use doctrine, which permits for copyright infringement in certain circumstances, calling it “unpersuasive.”

In March 2020, the Internet Archive, a San Francisco-based nonprofit, launched a program called the National Emergency Library, or NEL. Library closures caused by the pandemic had left students, researchers, and readers unable to access millions of books, and the Internet Archive has said it was responding to calls from regular people and other librarians to help those at home get access to the books they needed.

In H.G. Wells’ 1,897 science fiction novel, “The Invisible Man,” the protagonist invents a serum that makes the cells in his body transparent by controlling how they bend light.

More than 100 years later, scientists have discovered a real-life version of the substance: A commonly used food coloring can make the skin of a mouse temporarily transparent, allowing scientists to see its organs function, according to a new study published Thursday in the journal Science.

The breakthrough could revolutionize biomedical research and, should it be successfully tested in humans, have wide-ranging applications in medicine and health care, such as making veins more visible to draw blood.

The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it. Some patients even experienced a 10,000-fold improvement in their vision after receiving the highest dose of the therapy, according to researchers from the Perelman School of Medicine at the University of Pennsylvania who co-led the clinical trial published in The Lancet.

“That 10,000-fold improvement is the same as a patient being able to see their surroundings on a moonlit night outdoors as opposed to requiring bright indoor lighting before treatment,” said the study’s lead author, Artur Cideciyan, Ph.D., a research professor of Ophthalmology and co-director of the Center for Hereditary Retinal Degenerations.

“One patient reported for the first time being able to navigate at midnight outdoors only with the light of a bonfire.”