Lifeboat Foundation

Within the body, cells involved in specific functions, like immune response and secretion, are equipped with granules, which are small membrane-bound compartments containing enzymes, proteins, or other molecules. In neutrophils, the so-called azurophilic (or primary) granules contain enzymes that are involved in the initial response to an infection.

MPO-based E-101 is the first wound and systemically safe antiseptic, with a safety profile comparable to saline, that is effective in physiological conditions.

Myeloperoxidase, or MPO, is one of the most important of such enzymes for the immune system’s ability to destroy pathogens. Allen has been studying the physiological role of MPO since 1971. Using chemiluminescence and metabolic studies he has been able to study the complex and finely regulated mechanism of NADPH oxidase driven MPO action in microbicidal activity.

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells.

The study demonstrates how these proteins collaborate in so-called “hubs” to repair DNA damage. This knowledge offers opportunities to improve cancer therapies and other treatments where DNA repair is essential. The researchers published their findings in Nature Communications on November 21.

DNA is the molecule that carries our genetic information. It can be damaged by normal cellular processes as well as external factors such as UV radiation and chemicals. Such damage can lead to breaks in the DNA strand. If DNA damage is not properly repaired, mutations can occur, which may result in diseases like cancer. Cells use repair systems to fix this damage, with specialized proteins locating and binding to the damaged regions.

Summary: Researchers have demonstrated how brain activity can predict behavior in urban environments, providing a roadmap for improving urban planning. Using functional MRI scans, the study identified activity in the brain’s reward system, specifically the ventromedial prefrontal cortex, as a key predictor of why people visit certain urban areas.

Participants rated photos of Lisbon’s urban spaces, and their brain responses were linked to visitation patterns, showing that people are drawn to areas of perceived value. This research suggests urban design can prioritize environments that align with cognitive and emotional well-being.

Neurourbanism, the emerging field behind this study, offers tools to design cities that enhance livability and sustainability. By focusing on human-centered approaches, cities can improve efficiency, mobility, and resident happiness.

Bioelectronics research and development of implants made of electrically conductive materials for disease treatment is advancing rapidly. However, bioelectronic treatment is not without complications. Researchers at Lund University in Sweden have taken another step forward by developing a refined method to create detailed and tissue-friendly bioelectronics.

In a study published in Advanced Science, the researchers describe how they can use light to create electrically conductive materials directly in the body, showing promising results in animal trials.

Bioelectronics is successfully used for treating heart arrhythmia, epilepsy, and neurodegenerative diseases like Parkinson’s, to name a few. However, it’s well known that today’s bioelectrodes and implantation methods require the tissue to adapt to the electrodes, rather than the other way around. This can lead to complications.

The United States Food and Drug Administration has just approved the first-ever clinical trial that uses CRISPR-Cas13 RNA editing. Its aim is to treat an eye disease called wet age-related macular degeneration that causes vision loss in millions of older people worldwide.

This trial marks a new frontier in gene therapy —the process of treating or curing medical conditions by changing a person’s genes.

What makes it special is the fact the therapy targets RNA, instead of DNA. So, what does that mean, and why should we be excited?

Life extension technologies: Gene editing, Senolytics & more. Unlocking human longevity secrets.

We can already tinker with human DNA to treat diseases. But being able to edit RNA allows for even more precision – and fewer risks.

Influenza, commonly known as the flu, is an infectious disease caused by fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin one to four (typically two) days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children. may progress to pneumonia from the virus or a subsequent bacterial infection. Other complications include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease.

There are four types of virus: types A, B, C, and D. Aquatic birds are the primary source of epidemics, and C virus causes a mild infection, primarily in children. D virus can infect humans but is not known to cause illness. In humans, viruses are primarily transmitted through respiratory droplets from coughing and sneezing. Transmission through aerosols and surfaces contaminated by the virus also occur.

Frequent hand washing and covering one’s mouth and nose when coughing and sneezing reduce transmission, as does wearing a mask. Annual vaccination can help to provide protection against viruses, particularly A virus, evolve quickly, so flu vaccines are updated regularly to match which strains are in circulation. Vaccines provide protection against A virus subtypes H1N1 and H3N2 and one or two B virus subtypes. infection is diagnosed with laboratory methods such as antibody or antigen tests and a polymerase chain reaction (PCR) to identify viral nucleic acid. The disease can be treated with supportive measures and, in severe cases, with antiviral drugs such as oseltamivir. In healthy individuals, is typically self-limiting and rarely fatal, but it can be deadly in high-risk groups.

Background: The simplified Pulmonary Embolism Severity Index (sPESI) has limitations when evaluating acute pulmonary embolism (PE) in patients with concurrent malignancy. Despite its utility in predicting outcomes among cancer patients, the role of the Eastern Cooperative Oncology Group Performance Status (ECOG PS) in acute PE remains underexplored. This study aims to assess the prognostic significance of ECOG PS ≥ 3 on short-and long-term mortality in acute PE with malignancy, correlating it with the sPESI.

Methods and results: We retrospectively analyzed 44 hemodynamically stable acute PE patients with unresectable or metastatic malignancies ineligible for curative treatment at Kameda Medical Center, a tertiary medical facility in Japan, from April 1, 2019, to March 2, 2023. Of these patients, 16 (36.4%) had ECOG PS ≥ 3.